2010 Football Schedule
| Date | Opponent | Location | Time | Result | Score | Record |
| Sept. 4 | University of South Alabama |
Mobile, Ala. |
5:00 |
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| Sept. 11 | Kentucky Wesleyan University |
Owensboro, Ky. |
7:00 |
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| Sept. 18 | Shorter College | Pikeville, Ky. |
1:30 |
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| Sept. 25 | Faulkner University |
Montgomery, Ala. |
2:30 |
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| Oct. 2 | * Campbellsville University |
Pikeville, Ky. | 1:30 |
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| Oct. 9 | * Lindsey Wilson College |
Columbia, Ky. |
2:30 |
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| Oct. 16 | * Georgetown College | Georgetown, Ky. | 1:30 |
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| Oct. 23 | * U.Va.-Wise | Pikeville, Ky. |
1:30 |
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| Nov. 6 | * WVU Tech |
Pikeville, Ky. | 1:30 |
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| Nov. 13 | * Kentucky Christian University |
Pikeville, Ky. | 5:00 |
An asterisk (*) indicates a Mid-South Conference East Division game.
All game times Eastern.